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The combination of PRP and hyaluronic acid is a promising treatment for improving the appearance of the face, since it offers an increase in skin elasticity, compared to the application of these two treatments alone. This conclusion is not only based on the empirical opinion of experts but is scientifically proven by various studies.
One of them was carried out by the Department of Plastic and Aesthetic Reconstructive Surgery, Henri Mondor Hospital, France and was published in the Aesthetic Surgery Journal.
“Deteriorating skin appearance is due to loss of elasticity and firmness. It is directly related to age and hereditary factors, but also to certain aggravating habits, such as smoking and exposure to the sun.
In recent years, the demand for treatments that improve the appearance of the face has increased significantly, given the increase in the elderly population, which, however, is much more active than in the past, takes care of its health and figure and wishes to feel and to look handsome”, notes o George VelimbasakisMD, FEBOPRAS, Plastic Reconstructive and Aesthetic Surgeon.
Aesthetic facial treatments have evolved accordingly to meet the demands, depending on the age and needs of the skin. Minimally invasive ways of rejuvenating it have been developed, which painlessly and in a few minutes go back in time, highlighting its unique characteristics.
Mesotherapy is one of them. It is a minimally invasive medical technique that consists of intradermal injections of nutrients, vitamins or enzymes in the area that needs improvement. This is achieved by releasing growth factors and stimulating fibroblasts to naturally activate collagen and elastin fiber synthesis.
It has been introduced to plastic surgery in the last decade and is beneficial both in younger people to reduce wrinkles and restore skin firmness, and in older people to restore elasticity and firmness.
Instead of nutrients, the patient’s own blood can be injected. Autologous platelet-rich plasma (α-PRP) mesotherapy is performed by injecting a small amount of the patient’s own blood after it has been collected and centrifuged. Red blood cells are removed in the process, leaving plasma with a high concentration of platelets, sometimes with leukocytes, which is re-injected into the skin and offers a wide range of therapeutic benefits.
The American Society of Plastic Surgeons, which has been tracking the progress and popularity of this treatment since 2015, reports that its use for cosmetic purposes has increased by 25% in the last four years.
Hyaluronic acid, on the other hand, is a natural component of the skin, one of the main components of the extracellular matrix, which stimulates cells and contributes to tissue regeneration. Its levels decrease over time and skin looks more aged as it loses moisture and volume and is not adequately protected from the sun.
Thus, intradermal injections of hyaluronic acid have become one of the most popular treatments used today in aesthetic dermatology for its replenishment and rejuvenation.
The combination of these two treatments seems to have spectacular results, without causing side effects. The French study proves it.
Researchers wanting to investigate and evaluate the combined effect of hyaluronic acid (HA) injections and autologous platelet-rich plasma (α-PRP) on facial skin rejuvenation selected 93 patients over 40 years of age who had wrinkles, dull and dry skin, with loss of elasticity and firmness.
The participants were divided into 3 groups, to undergo a series of 3 treatment sessions with injection of α-PRP, hyaluronic acid or a combination of α-PRP and HA in the cheeks.
They found that the combination treatment resulted in a highly significant improvement in overall facial appearance, compared to treatment with α-PRP or HA alone. Those who received combination therapy showed a 20%, 24% and 17% increase in FACE-Q (patient satisfaction with their facial appearance) score at 1, 3 and 6 months after treatment, respectively. For the hyaluronic acid-only group, the improvement in FACE-Q score was 12%, 11%, and 6%, while for the α-PRP group, the improvement was 9%, 11%, and 8%, respectively.
Biophysical measurements showed significantly improved skin elasticity for the group treated with combination therapy, compared to the groups treated with α-PRP or HA alone. No group experienced serious adverse events.
“It appeared that the combination of α-PRP and hyaluronic acid improved skin elasticity, firmness and radiance. It is clear, that is, that when the two treatments are used together they offer a more powerful therapeutic effect to those who wish to rejuvenate the skin of the face, which looks younger, brighter, more elastic and firmer. In fact, the findings showed that skin firmness improved more and more in patients who were over 50 years old.
In addition to hyaluronic acid, α-PRP can also be combined with microneedling, for the overall restoration of the appearance of the face, which includes the smoothing of wrinkles, the reduction of pore diameter, the disappearance of skin spots and the improvement of scars.
Those with superficial or deeper wrinkles, sagging and loss of volume and firmness of the skin, dull and dehydrated skin, dark circles, dilated pores but also scars from acne or injuries can benefit from these treatments,” concludes doctor Georgios Velimbasakis.
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